Perindopril preserves left ventricular function in X-linked Duchenne muscular dystrophy
نویسندگان
چکیده
منابع مشابه
Left ventricular noncompaction in Duchenne muscular dystrophy
BACKGROUND Left ventricular noncompaction (LVNC) describes deep trabeculations in the left ventricular (LV) endocardium and a thinned epicardium. LVNC is seen both as a primary cardiomyopathy and as a secondary finding in other syndromes affecting the myocardium such as neuromuscular disorders. The objective of this study is to define the prevalence of LVNC in the Duchenne Muscular Dystrophy (D...
متن کاملEffect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy.
OBJECTIVES The aim of this research was to examine the effects of perindopril on cardiac function in patients with Duchenne muscular dystrophy (DMD). BACKGROUND Duchenne muscular dystrophy, an inherited X-linked disease, is characterized by progressive muscle weakness and myocardial involvement. METHODS In phase I, 57 children with DMD and a left ventricular ejection fraction (LVEF) >55% (m...
متن کاملLeft ventricular T2 distribution in Duchenne Muscular Dystrophy
BACKGROUND Although previous studies have helped define the natural history of Duchenne muscular dystrophy (DMD)-associated cardiomyopathy, the myocardial pathobiology associated with functional impairment in DMD is not yet known.The objective of this study was to assess the distribution of transverse relaxation time (T2) in the left ventricle (LV) of DMD patients, and to determine the associat...
متن کاملLeft ventricular function by echocardiography correlates poorly with cardiac MRI measures in Duchenne muscular dystrophy
Background Duchenne muscular dystrophy (DMD) causes skeletal muscle weakness and cardiomyopathy (CM). Current recommendations are for annual left ventricular (LV) function assessment after age 10 years. Although echocardiographic image quality in DMD patients can be affected by scoliosis and adipose tissue, recent reviews recommend echocardiography as the standard imaging modality. We hypothesi...
متن کاملP164: Adeno-Associated Viral Vectors in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
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ژورنال
عنوان ژورنال: European Heart Journal Supplements
سال: 2007
ISSN: 1554-2815,1520-1554
DOI: 10.1093/eurheartj/sum036